The responsibilities of the Palau Register of Historic Places include:

1. Nominating and registering sites to the Palau Register of Historic Places.
2. Maintaining the national list of historic sites eligible to be nominated to the National Historic Register.
3. Monitoring permitted and non-permitted undertakings for compliance with the historic preservation law.
4. Preservation and protection of all artifacts, documents, and other materials with historical or cultural value held in the Register archive.
5. Restoration of registered sites.
6. Maintaining the Palau Research Library.